Cannabidiol Mitigates Opioid Reward On Conditioned Place Preference In Mice

Author

James Roland Markos, University of Mississippi. Sally McDonnell Barksdale Honors College

Date of Award

2017

Document Type

Undergraduate Thesis

Department

Psychology

First Advisor

Kenneth Sufka

Relational Format

Dissertation/Thesis

Abstract

This study sought to determine whether the cannabis constituent, cannabidiol (CBD), is able to attenuate morphine reward in the conditioned place preference (CPP) paradigm. Mice received IP injections of either saline or morphine and increasing doses of CBD that were paired with a distinct environment in the CPP apparatus. Morphine-produced place preference was dose-dependently blocked by CBD. Furthermore, none of the tested doses of CBD exhibited reward or aversion. The finding that CBD blocks opioid reward suggests CBD may be useful as an abuse deterrent, particularly in the setting of opioid use for pain management.

Recommended Citation

Markos, James Roland, "Cannabidiol Mitigates Opioid Reward On Conditioned Place Preference In Mice" (2017). Honors Theses. 417.
https://egrove.olemiss.edu/hon_thesis/417

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