Design and Synthesis of Sigma-1 Probe for Positron Emission Tomography (PET) Imaging

Author

May Ly, University of Mississippi. Sally McDonnell Barksdale Honors College

Date of Award

2015

Document Type

Undergraduate Thesis

Department

Biomolecular Sciences

First Advisor

Christopher McCurdy

Relational Format

Dissertation/Thesis

Abstract

Sigma-1 receptor radioligands have the potential to detect and monitor various neurological diseases. Because sigma-1 receptors are believed to be associated with numerous psychiatric conditions and neurodegenerative diseases, radioligands for sigma-1 receptors have the potential to serve as novel diagnostic tools and may be useful in assessing treatment effectiveness. A benzothiazolone 18F-labeled sigma-1 receptor ligand, CM304, has demonstrated promise as a specific positron emission tomography radiotracer for visualizing sigma-1 receptors in living subjects. Based on CM304, backup molecules were created to improve the overall drug profile, including half- life and bioavailability.

Recommended Citation

Ly, May, "Design and Synthesis of Sigma-1 Probe for Positron Emission Tomography (PET) Imaging" (2015). Honors Theses. 679.
https://egrove.olemiss.edu/hon_thesis/679

Accessibility Status

Searchable text