Modeling Nitroglycerin-Induced Migraine in Rats

Author

Stephanie Staszko, University of Mississippi. Sally McDonnell Barksdale Honors College

Date of Award

2014

Document Type

Undergraduate Thesis

Department

Psychology

First Advisor

Kenneth Sufka

Relational Format

Dissertation/Thesis

Abstract

The present research sought to determine whether nitroglycerin (NTG) produced changes in clinically relevant endophenotypes of migraine. Rats were given a single injection of NTG or vehicle with the following dependent measures recorded: Rat Grimace Scale, hot and cold tail flick latency, Rotor-Rod performance, and photophobia and movement in traditional and modified light/dark boxes. NTG increased rat grimace scores but did not produce thermal allodynia nor photophobia. Further, NTG produced paradoxical increases in Rotor-Rod performance and movement. These results demonstrate that a single injection of NTG does not produce behaviors that parallel clinical symptoms of migraine.

Recommended Citation

Staszko, Stephanie, "Modeling Nitroglycerin-Induced Migraine in Rats" (2014). Honors Theses. 871.
https://egrove.olemiss.edu/hon_thesis/871

Accessibility Status

Searchable text