Psammaplins Selectively Target Triple-Negative Metastatic Breast Tumor Cells that are Genetically Programmed to Colonize Specific Organs

Author

Thuy Phuong Le, University of Mississippi. Sally McDonnell Barksdale Honors College

Date of Award

2017

Document Type

Undergraduate Thesis

Department

Chemistry and Biochemistry

First Advisor

Yu-Dong Zhou

Relational Format

Dissertation/Thesis

Abstract

Five bromotyrosine-derived marine sponge metabolites, four psammaplins (1 — 4) and the psammaplin dimer, bisaprasin (5) were isolated from a lipid extract sample of the marine sponge Dendrilla lacunosa. Â Psammaplins act as histone deacetylase (HDAC) inhibitors that alter cellular gene expression. Â The D. lacunosa psammaplins activated the oxygen regulated transcription factor HIF-1 (hypoxia-inducible factor-1) in T47D human breast tumor cells and displayed cell line specific effects against aggressive organotropic metastatic cell lines that were derived from triple-negative MDA-MB-231 human breast tumor cells.

Recommended Citation

Le, Thuy Phuong, "Psammaplins Selectively Target Triple-Negative Metastatic Breast Tumor Cells that are Genetically Programmed to Colonize Specific Organs" (2017). Honors Theses. 915.
https://egrove.olemiss.edu/hon_thesis/915

Accessibility Status

Searchable text