Neuroscience Research Showcase
The effects of estradiol and genistein on cerebellar neuroprotection in zebra finches
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Description
Introduction:
- Brain damage causes a secondary wave of degeneration
- Aromatase is upregulated in glia post-injury
- Aromatase (AROM) converts testosterone to estradiol (E2) E2 is neuroprotective and limits cell death
- E2 is linked to cancer, stroke, and male infertility Genistein (GEN) is a soybean phytoestrogen with strong estrogen receptor beta (ERβ) affinity
- Genistein could be used clinically for neuroprotection
- ERβ receptors are abundant in the cerebellum AROM expression in the cerebellum is constitutively low
- Zebra Finch (ZF) brains have high neuroplasticity
- The ZF cerebellum is ideal for neuroplasticity research
All authors are affiliated with the University of Mississippi Department of Biology.
Publication Date
4-4-2024
Relational Format
Presentation
Disciplines
Neurosciences
Recommended Citation
Thompson, Grace; Breaux, Renee E.; McFatridge, Emily; Chong, Sarah; Zadronzy, Ethan; Blair, Estelle; and Day, Lainy B., "The effects of estradiol and genistein on cerebellar neuroprotection in zebra finches" (2024). Neuroscience Research Showcase. 23.
https://egrove.olemiss.edu/neuro_showcase/23
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