The effects of estradiol and genistein on cerebellar neuroprotection in zebra finches

Presenter(s)

Grace Thompson, University of Mississippi
Renee E. Breaux, University Of Mississippi
Emily McFatridge, University of Mississippi
Sarah Chong, University of Mississippi
Ethan Zadronzy, University of Mississippi
Estelle Blair, University of Mississippi
Lainy B. Day, University of Mississippi

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Description

Introduction:

• Brain damage causes a secondary wave of degeneration
• Aromatase is upregulated in glia post-injury
• Aromatase (AROM) converts testosterone to estradiol (E₂) E₂ is neuroprotective and limits cell death
• E₂ is linked to cancer, stroke, and male infertility Genistein (GEN) is a soybean phytoestrogen with strong estrogen receptor beta (ERβ) affinity
• Genistein could be used clinically for neuroprotection
• ERβ receptors are abundant in the cerebellum AROM expression in the cerebellum is constitutively low
• Zebra Finch (ZF) brains have high neuroplasticity
• The ZF cerebellum is ideal for neuroplasticity research

All authors are affiliated with the University of Mississippi Department of Biology.

Publication Date

4-4-2024

Relational Format

Presentation

Disciplines

Neurosciences

Recommended Citation

Thompson, Grace; Breaux, Renee E.; McFatridge, Emily; Chong, Sarah; Zadronzy, Ethan; Blair, Estelle; and Day, Lainy B., "The effects of estradiol and genistein on cerebellar neuroprotection in zebra finches" (2024). Neuroscience Research Showcase. 23.
https://egrove.olemiss.edu/neuro_showcase/23

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