Posters and Spotlights
The Role of Poly(methacrylamidoglucopyranose)(PMAG) Nanoparticles in inducing Apoptosis in Breast Cancer Cells in Vitro
Start Date
30-4-2025 11:30 AM
Document Type
Event
Description
Poster Presenter: Joshua Anderson
Research Team: Joshua Anderson, Kenneth R. Hulugalla, Thomas A. Werfel
Abstract: Nanomedicine offers a promising approach to cancer drug delivery but is hindered by the protein corona (PC) effect, where proteins coat nanoparticles (NPs), altering their stability, circulation, and targeting. While PEGylation is the standard method to reduce protein adsorption, PEG has drawbacks, including immune responses, accelerated clearance, and supply limitations. Our lab has demonstrated that poly(methacrylamidoglucopyranose) (PMAG) NPs outperform PEGylated NPs, exhibiting greater stability, reduced immune recognition, and enhanced cellular uptake. These advantages make PMAG a strong candidate for improving drug delivery efficacy. Building on this, we investigate PMAG’s role in inducing apoptosis in breast cancer cells in vitro, highlighting its therapeutic potential.
Relational Format
poster
Recommended Citation
Anderson, Joshua, "The Role of Poly(methacrylamidoglucopyranose)(PMAG) Nanoparticles in inducing Apoptosis in Breast Cancer Cells in Vitro" (2025). Showcase of Research and Scholarly Activity. 2.
https://egrove.olemiss.edu/ored_showcase/2025/posters/2
The Role of Poly(methacrylamidoglucopyranose)(PMAG) Nanoparticles in inducing Apoptosis in Breast Cancer Cells in Vitro
Poster Presenter: Joshua Anderson
Research Team: Joshua Anderson, Kenneth R. Hulugalla, Thomas A. Werfel
Abstract: Nanomedicine offers a promising approach to cancer drug delivery but is hindered by the protein corona (PC) effect, where proteins coat nanoparticles (NPs), altering their stability, circulation, and targeting. While PEGylation is the standard method to reduce protein adsorption, PEG has drawbacks, including immune responses, accelerated clearance, and supply limitations. Our lab has demonstrated that poly(methacrylamidoglucopyranose) (PMAG) NPs outperform PEGylated NPs, exhibiting greater stability, reduced immune recognition, and enhanced cellular uptake. These advantages make PMAG a strong candidate for improving drug delivery efficacy. Building on this, we investigate PMAG’s role in inducing apoptosis in breast cancer cells in vitro, highlighting its therapeutic potential.