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Description

Biomolecular footprinting is well-established for nucleic acids and proteins but lacks a method for carbohydrates. Glycan footprinting could enhance understanding of glycan interactions via mass spectrometry. We verified that CF3 labeled the model trisaccharide NAG3 across the oligosaccharide. We developed a quenching and reduction protocol for improved post-labeling analysis and the first radical covalent footprinting method for complex carbohydrates.

Publication Date

3-6-2025

Relational Format

poster

Disciplines

Pharmacy and Pharmaceutical Sciences

Accessibility Status

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Trifluoromethyl Carbohydrate Footprinting for Probing Protein Binding Components of Oligosaccharides Mixture

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