Skin Bleaching Among African and Afro-Caribbean Women in New York City: Primary Findings from a P30 Pilot Study

Authors

Emma K.T. Benn, Icahn School of Medicine at Mount Sinai
Richa Deshpande, Icahn School of Medicine at Mount Sinai
Ogonnaya Dotson-Newman, Icahn School of Medicine at Mount Sinai
Sharon Gordon, Icahn School of Medicine at Mount Sinai
Marian Scott, Icahn School of Medicine at Mount Sinai
Chitra Amarasiriwardena, Icahn School of Medicine at Mount Sinai
Ikhlas A. Khan, University of Mississippi School of Pharmacy
Yan Hong Wang, University of Mississippi School of Pharmacy
Andrew Alexis, Icahn School of Medicine at Mount Sinai
Bridget Kaufman, Icahn School of Medicine at Mount Sinai
Hector Moran, Hunter College
Chi Wen, Icahn School of Medicine at Mount Sinai
Christopher A.D. Charles, University of the West Indies
Novie O.M. Younger, Caribbean Institute for Health Research
Nihal Mohamed, Icahn School of Medicine at Mount Sinai
Bian Liu, Icahn School of Medicine at Mount Sinai

Document Type

Article

Publication Date

6-1-2019

Abstract

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Coinciding with the increase in sequenced bacteria, mining of bacterial genomes for biosynthetic gene clusters (BGCs) has become a critical component of natural product discovery. The order Myxococcales, a reputable source of biologically active secondary metabolites, spans three suborders which all include natural product producing representatives. Utilizing the BiG-SCAPE-CORASON platform to generate a sequence similarity network that contains 994 BGCs from 36 sequenced myxobacteria deposited in the antiSMASH database, a total of 843 BGCs with lower than 75% similarity scores to characterized clusters within the MIBiG database are presented. This survey provides the biosynthetic diversity of these BGCs and an assessment of the predicted chemical space yet to be discovered. Considering the mere snapshot of myxobacteria included in this analysis, these untapped BGCs exemplify the potential for natural product discovery from myxobacteria.

Relational Format

journal article

Recommended Citation

Benn, E. K. T., Deshpande, R., Dotson-Newman, O., Gordon, S., Scott, M., Amarasiriwardena, C., Khan, I. A., Wang, Y.-H., Alexis, A., Kaufman, B., Moran, H., Wen, C., Charles, C. A. D., Younger, N. O. M., Mohamed, N., & Liu, B. (2019). Skin Bleaching Among African and Afro-Caribbean Women in New York City: Primary Findings from a P30 Pilot Study. Dermatology and Therapy, 9(2), 355–367. https://doi.org/10.1007/s13555-019-0297-y

DOI

10.1007/s13555-019-0297-y