Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit

Authors

Jayachithra Ramakrishna Pillai, Ras Al Khaima Medical and Health Sciences University (RAK)
Adil Farooq Wali, Ras Al Khaima Medical and Health Sciences University (RAK)
Godfred Antony Menezes, Ras Al Khaima Medical and Health Sciences University (RAK)
Muneeb U. Rehman, College of Pharmacy

Document Type

Article

Publication Date

3-1-2022

Abstract

Physalis angulata L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. Physalis angulata leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content. The GC-MS technique investigated the chemical composition and structure of bioactive chemicals reported in extracts. The anticancer activity results revealed a decrease in the percentage of anticancer cells’ viability in a concentration-and time-dependent way. We also noticed morphological alterations in the cells, which we believe are related to Physalis angulata extracts. Under light microscopy, we observed that as the concentration of ethanolic extract (fruit and leaves) treated HeLa cells increased, the number of cells began to decrease.

Relational Format

journal article

Recommended Citation

Ramakrishna Pillai, J.; Wali, A.F.; Menezes, G.A.; Rehman, M.U.; Wani, T.A.; Arafah, A.; Zargar, S.; Mir, T.M. Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit. Molecules 2022, 27, 1480. https://doi.org/10.3390/molecules27051480

DOI

10.3390/molecules27051480

Accessibility Status

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