A Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications in 2018

Authors

Elias B. Chahine, Palm Beach Atlantic University
Spencer H. Durham, Harrison School of Pharmacy
Krutika N. Mediwala, Medical University of South Carolina
Daniel B. Chastain, University of Georgia
Timothy P. Gauthier, Baptist Health South Florida
Brandon K. Hill, University of Virginia Health System
Bruce M. Jones, St. Joseph's/Candler Health System
Jamie J. Kisgen, Sarasota Memorial Health Care System
Ashley H. Marx, UNC Health Care
Kayla R. Stover, University of Mississippi School of Pharmacy
Marylee V. Worley, Nova Southeastern University
Christopher M. Bland, University of Georgia
P. Brandon Bookstaver, University of South Carolina

Document Type

Article

Publication Date

10-15-2019

Abstract

© The Author(s) 2019 Phytochemical investigation of methanolic extract of Limonium leptophyllum (Plumbaginaceae), led to the isolation of 1 new isoflavonoid with a rare 5-membered dihydrofuran ring (1, leptoisoflavone A) and 8 known compounds. The known isolated compounds were identified as euchrenone b9 (2), auriculasin (3), kaempferol (4), avicularoside (5), myrice-tin-3-arabinoside (6), trans-N-feruloyltyramine (7), trans-N-caffeoyltyramine (8), and β-sitosterol (9). The crude methanolic extract exhibited moderate activity toward endocannabinoid receptors. Auriculasin (3) showed activity toward cannabinoid receptor type 1 (86.7% displacement with IC50 8.92 μM).

Relational Format

journal article

Recommended Citation

Chahine, E. B., Durham, S. H., Mediwala, K. N., Chastain, D. B., Gauthier, T. P., Hill, B. K., Jones, B. M., Kisgen, J. J., Marx, A. H., Stover, K. R., Worley, M. V., Bland, C. M., & Bookstaver, P. B. (2019). A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2018. Open Forum Infectious Diseases, 6(11), ofz450. https://doi.org/10.1093/ofid/ofz450

DOI

10.1093/ofid/ofz450