Faculty and Student Publications
Document Type
Article
Publication Date
12-1-2019
Abstract
© 2019 by the authors. Bioassay-guided fractionation of an EtOAc extract of the broth of the endophytic fungus Nemania sp. UM10M (Xylariaceae) isolated from a diseased Torreya taxifolia leaf afforded three known cytochalasins, 19,20-epoxycytochalasins C (1) and D (2), and 18-deoxy-19,20-epoxy-cytochalasin C (3). All three compounds showed potent in vitro antiplasmodial activity and phytotoxicity with no cytotoxicity to Vero cells. These compounds exhibited moderate to weak cytotoxicity to some of the cell lines of a panel of solid tumor (SK-MEL, KB, BT-549, and SK-OV-3) and kidney epithelial cells (LLC-PK11). Evaluation of in vivo antimalarial activity of 19,20-epoxycytochalasin C (1) in a mouse model at 100 mg/kg dose showed that this compound had weak suppressive antiplasmodial activity and was toxic to animals.
Relational Format
journal article
Recommended Citation
Slattery, M., Pankey, M. S., & Lesser, M. P. (2019). Annual Thermal Stress Increases a Soft Coral’s Susceptibility to Bleaching. Scientific Reports, 9(1), 8064. https://doi.org/10.1038/s41598-019-44566-9
DOI
10.1038/s41598-019-44566-9