Faculty and Student Publications
Document Type
Article
Publication Date
2-1-2019
Abstract
© 2019 by the authors. Astragalus is a very interesting plant genus, well-known for its content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing several activities, e.g., immunomodulating, antibacterial, antiviral and hepatoprotective. This inspired us to analyze the Bulgarian endemic A. aitosensis (Ivanisch.) to obtain deeper information about its phenolic components. We used extensive chromatographic separation of A. aitosensis extract to obtain seven phenolic compounds (1–7), which were identified using combined LC-MS and NMR spectral studies. The 1D and 2D NMR analyses and HR-MS allowed us to resolve the structures of known compounds 5–7 as isorhamnetin-3-O-robinobioside, isorhamnetin-3-O-(2,6-di-O-α-rhamno-pyranosyl-β-galactopyranoside), and alangiflavoside, respectively, and further comparison of these spectral data with available literature helped us with structural analysis of newly described flavonoid glycosides 1–4. These were described in plant source for the first time.
Relational Format
journal article
Recommended Citation
Nicholson, H. E., Alsharif, W. F., Comeau, A. B., Mesangeau, C., Intagliata, S., Mottinelli, M., McCurdy, C. R., & Bowen, W. D. (2019). Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[ d ]oxazol-2(3 H )-one (SN79) Derivatives. Journal of Pharmacology and Experimental Therapeutics, 368(2), 272–281. https://doi.org/10.1124/jpet.118.253484
DOI
10.1124/jpet.118.253484