Date of Award
1-1-2016
Document Type
Thesis
Degree Name
M.S. in Chemistry
Department
Chemistry and Biochemistry
First Advisor
Susan Pedigo
Second Advisor
Michael Mossing
Third Advisor
Robert J. Doerksen
Relational Format
dissertation/thesis
Abstract
Neural and epithelial cadherin are adhesion proteins intensely studied by our lab. Although the sequence, structure, and conformation are similar for the two cadherins, there are several physical properties that differ: dimerization affinity, dimerization kinetics, intermediate structure, and critical residues for dimerization. In the presence of calcium, cadherins are in equilibrium between monomeric and dimeric states, and the scope of this thesis focuses on monomeric cadherin. These molecular dynamics evaluations are based on the testing of specific hypotheses regarding the intramolecular interactions of neural and epithelial cadherin. We particularly focus on interactions involving critical residues at the N-terminus of the proteins, the hydrophobic core residues, and the ionic surface area.
Recommended Citation
Fan, Lianyi, "Investigation of Neural and Epithelial Cadherin Monomer Properties Using a Molecular Dynamics Approach" (2016). Electronic Theses and Dissertations. 1289.
https://egrove.olemiss.edu/etd/1289