Date of Award
1-1-2017
Document Type
Thesis
Degree Name
M.S. in Pharmaceutical Science
Department
Pharmaceutics and Drug Delivery
First Advisor
Seongbong Jo
Second Advisor
Michael A. Repka
Third Advisor
Soumyajit Majumdar
Relational Format
dissertation/thesis
Abstract
The objective of this study was to develop a novel multiblock copolymer (MBCP) with temperature/pH dual-sensitivity which undergoes gelation at body temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal linker, 2,2-bis(aminoethoxy)propane (BAP) and Pluronic® P104 using L-lysine diisocyanate ethyl ester (LDI) or 1,6-Diisocyanatohexane (HDI). The gelation temperature of 20% (w/v) MBCP was in the range of 29 to 31 ºC when tested with three different techniques: rheometer, test tube inversion method, and falling ball method. The polymer shopH-triggered degradation and drug release with nile red and irinotecan. The ketal linker connecting Pluronic® was cleaved and resulted in smaller molecular weight strain causing change in sol-gel transition temperature and critical micelle concentration. This mechanism confers the synthesized polymer with pH/temperature instigated drug release properties and thus can be used for targeted drug delivery applications.
Recommended Citation
Lee, Hyung Kyung, "Synthesis and characterization of pH/temperature dual sensitive multiblock copolymer for drug delivery" (2017). Electronic Theses and Dissertations. 1335.
https://egrove.olemiss.edu/etd/1335