Electronic Theses and Dissertations

Date of Award

1-1-2015

Document Type

Dissertation

Degree Name

Ph.D. in Pharmaceutical Sciences

Department

Biomolecular Sciences

First Advisor

Michael A. Repka

Second Advisor

Samir A. Ross

Third Advisor

S. Narasimha Murthy

Relational Format

dissertation/thesis

Abstract

Hot melt extrusion (HME) is an old technology that has been recently adapted to be used in the pharmaceutical industry. HME is a continuous process that is widely used to produce a solid dispersion matrix. The aim of this dissertation is to evaluate different factors that will affect the pharmaceutical formulation properties that are produced using HME. For HME, there are different variables that will affect the product quality such as processing parameters, material selection, material ratio, and the presence of gas or moisture. One aim of this study is to find the most significant factor that affects the product properties using the simplest design of experiment. Material selection and the ratio between the materials will be extensively evaluated using carbamazepine as a model drug. Moisture content and gas introduced during the process will be assessed and illustrate the best method to remove them. Process parameters show a significant effect on the product quality. Polymer selection and the ratio between the polymers show a great impact on drug dissolution and stability studies. Effective degassing has successfully enhanced the overly product quality features such as dissolution, shape, drug content and stability.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.