Date of Award
2019
Document Type
Thesis
Degree Name
M.S. in Pharmaceutical Science
Department
Pharmaceutics and Drug Delivery
First Advisor
Chalet Tan
Second Advisor
Walter Chambliss
Third Advisor
Seongbong Jo
Relational Format
dissertation/thesis
Abstract
Parasitic diseases are a severe threat to people and animals. Praziquantel is the most comanti-parasitic drug with high efficiency, and it has been used to treat parasitic diseases for many years. However, it has very strong gastrointestinal and liver metabolism that leads to a strong first-pass effect and a short half-life. Additionally, the frequent oral administration was inconvenient for the large livestock. To overcome these drawbacks, this study aimed to develop an extended-release thermosensitive hydrogel formulation that was applicable to the injectable administration. The praziquantel-loaded hydrogel formulation based on poloxamer 407 (20%, w/v) was prepared, and two strategies for modifications of poloxamer 407 hydrogel were studied. One of them was the formulation consisting of PEG-DSPE/TPGS mixed micelles-poloxamer 407 hydrogel hybrid system; another was the poloxamer 407 hydrogel adding with HPMC as an adhesive. These hydrogel formulations had a reversible sol-gel transition property at approximate 26 °C and obtained high loading efficiencies and storage stability. in-vitro release studies, as well as in-vivo pharmacokinetic studies, were conducted to evaluate the extended-release effect, and the bioavailability of several optimized formulations of praziquantel was calculated. The in-vitro release of praziquantel was prolonged when loading into poloxamer 407 hydrogel. Both the modifications of poloxamer 407 hydrogel, by adding HPMC as well as utilizing PEG- DSPE/TPGS mixed micelle as a secondary delivery vehicle obtained the relatively better extended-release profiles than the original poloxamer 407 hydrogel. The pharmacokinetic studies indicated that the poloxamer 407 hydrogel formulation has a relatively high bioavailability and prolonged release profile, but both two modifications failed to obtain a significant improvement of an extended-release characteristic compared with the original hydrogel solution.
Recommended Citation
Feng, Sheng, "Design of Thermosensitive Hydrogel for Extended-Release of Praziquantel" (2019). Electronic Theses and Dissertations. 1593.
https://egrove.olemiss.edu/etd/1593