Date of Award
2019
Document Type
Dissertation
Degree Name
Ph.D. in Pharmaceutical Sciences
Department
Pharmaceutics and Drug Delivery
First Advisor
Soumyajit Majumdar
Second Advisor
Mahavir Chougule
Third Advisor
Michael A. Repka
Relational Format
dissertation/thesis
Abstract
The Chapter II focuses on formulation of an optimized and robust amphotericin B ocular formulation with prolonged precorneal residence and ocular tissue concentration at par or superior to the marketed preparations. Additionally, demonstrating stability of amphotericin B formulations in presence of preservative in comparison to marketed preparation, making it an ideal choice of formulation for multi-dosing. As mentioned earlier, we optimized PEGylated nanostructured lipid carriers (PEG-NLC-AmB) for ocular delivery of amphotericin B. The formulations could be autoclaved with at least one-month stability and in vivo ocular biodistribution was statistically insignificantly different compared to AmBisome®. To accomplish the aim, strategies such as mucoadhesion and/or viscosity enhancement were investigated. In this regard, PEG-NLC-AmB entrapped in ion triggered hydrogels using gellan gum (mucoadhesive) and chitosan (mucoadhesive and permeation enhancer) coated PEG-NLC-AmB were formulated and characterized.
Recommended Citation
Lakhani, Prit Manish, "PEGylated Nanostructured Lipid Carries for Amphotericin B Ocular Delivery" (2019). Electronic Theses and Dissertations. 1634.
https://egrove.olemiss.edu/etd/1634