Electronic Theses and Dissertations

Date of Award

2019

Document Type

Dissertation

Degree Name

Ph.D. in Pharmaceutical Sciences

Department

Pharmaceutics and Drug Delivery

First Advisor

Soumyajit Majumdar

Second Advisor

Mahavir Chougule

Third Advisor

Michael Repka

Relational Format

dissertation/thesis

Abstract

The Chapter II focuses on formulation of an optimized and robust amphotericin B ocular formulation with prolonged precorneal residence and ocular tissue concentration at par or superior to the marketed preparations. Additionally, demonstrating stability of amphotericin B formulations in presence of preservative in comparison to marketed preparation, making it an ideal choice of formulation for multi-dosing. As mentioned earlier, we optimized PEGylated nanostructured lipid carriers (PEG-NLC-AmB) for ocular delivery of amphotericin B. The formulations could be autoclaved with at least one-month stability and in vivo ocular biodistribution was statistically insignificantly different compared to AmBisome®. To accomplish the aim, strategies such as mucoadhesion and/or viscosity enhancement were investigated. In this regard, PEG-NLC-AmB entrapped in ion triggered hydrogels using gellan gum (mucoadhesive) and chitosan (mucoadhesive and permeation enhancer) coated PEG-NLC-AmB were formulated and characterized.

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