Date of Award
2019
Document Type
Dissertation
Degree Name
Ph.D. in Pharmaceutical Sciences
Department
Pharmaceutics and Drug Delivery
First Advisor
Michael A. Repka
Second Advisor
Soumyajit Majumdar
Third Advisor
S. Narasimha Murthy
Relational Format
dissertation/thesis
Abstract
Solid self-emulsifying drug delivery systems were developed instead of a conventional liquid system. Solid surfactants was chosen to emulsify lipids with different HLB properties. Type of surfactant, type of lipid, Lipid/surfactant L/S ratio, feed rate, screw speed and screw configuration, were the formulation and process parameters evaluated. Solid self-emulsifying drug delivery systems were successfully developed on the hot-melt extruder for the first time which is a continuous processing technology.
Recommended Citation
Thipsay, Priyanka, "Application of Quality by Design and Process Analytical Technology towards Hot-Melt Extrusion Processes" (2019). Electronic Theses and Dissertations. 1710.
https://egrove.olemiss.edu/etd/1710