Date of Award
2019
Document Type
Dissertation
Degree Name
Ph.D. in Pharmaceutical Sciences
Department
Pharmaceutics and Drug Delivery
First Advisor
Michael A. Repka
Second Advisor
Mahavir Chougule
Third Advisor
John O'Haver
Relational Format
dissertation/thesis
Abstract
New drug product development is a time consuming and costly process. One of the significant challenges is the poor aqueous solubility of many active pharmaceutical ingredients (APIs). Among those techniques, hot-melt extrusion(HME) is optimal for pharmaceutical solid dispersion development because of it free of using an organic solvent, easy scale up, and suitable for continuous processing with ensured optimal quality control.
Recommended Citation
Zhang, Jiaxiang, "Novel Application of Melt Extrusion and Additive Manufacturing on Developing Diverse Dosages" (2019). Electronic Theses and Dissertations. 1720.
https://egrove.olemiss.edu/etd/1720