Date of Award
1-1-2019
Document Type
Thesis
Degree Name
M.S. in Pharmaceutical Science
First Advisor
S. Narasimha Murthy
Second Advisor
Walter G. Chambliss
Third Advisor
Michael A. Repka
School
University of Mississippi
Relational Format
dissertation/thesis
Abstract
Voriconazole (VRC) was selected as a model drug for preparation of Oil/PEG cream consisting of PEG 2000, PEG 400 and propylene glycol after performing drug-excipient compatibility studies. Twin screw processor with a 10 mm co-rotating twin screw configuration was used for preparation of oil/PEG creams. Creams prepared using twin-screw processor were characterized for the following: Differential Scanning Calorimetry (DSC), pH, Solvent activity (as)), viscosity, drug content uniformity, in vitro drug release testing (IVRT) and in vitro permeation testing (IVPT) using human cadaver skin. Creams are heterogenous biphasic semi-solid preparations consisting of oil and aqueous phases, wherein one phase is dispersed in the other and stabilized using a suitable emulsifier. The active pharmaceutical ingredient is either dissolved or dispersed in continuous or dispersed phase of the formulation. Water is the most comand the major constituent in the preparation of creams. However, certain moisture sensitive drugs like mechlorethamine, acyclovir, itraconazole and ketoconazole are liable to degradation in presence of water thereby decreasing the stability of the formulation. Hence, there is a need for formulation suitable for incorporating water sensitive drugs. Creams prepared with polyethylene glycol instead of water could be an alternative to creams prepared using water to improve the stability of the drug. Moreover, PEGs are generally used as drug penetration enhancers and solubilizers in cream preparations. The objective of present study was to develop and optimize Oil in PEG creams suitable for incorporating moisture sensitive drugs and to investigate the feasibility of twin-screw processor in the continuous manufacturing of topical semi-solid cream formulation.
Recommended Citation
Shettar, Abhishek Shivashankar, "Development Of Topical Oil/Peg Creams Of Voriconazole" (2019). Electronic Theses and Dissertations. 1942.
https://egrove.olemiss.edu/etd/1942