Date of Award
1-1-2022
Document Type
Thesis
Degree Name
M.S. in Pharmaceutical Science
First Advisor
Michael Repka
Second Advisor
Eman Ashour
Third Advisor
Walt Chambliss
School
University of Mississippi
Relational Format
dissertation/thesis
Abstract
Transdermal drug delivery enables efficient local and systematic drug delivery while offering advantages such as non-invasiveness, patient compliance, and avoidance of first pass metabolism compared to parenteral administration. Due to strong and the multi-layered structure of the skin creates complex barriers which makes the delivery of therapeutic agents across the skin becomes challenging. Microneedles have been shown to deliver drugs through the transdermal route by penetrating the skin’s protective barrier, stratum corneum (SC) and creating a pathway for drug permeation to the dermal tissue. Traditionally, microneedles were fabricated using various types of materials and process such as casting, injection moulding, micromoulding, pressure moulding. Recently, additive manufacturing (AM) or three-dimensional printing (3DP) has been used for fabrication of MNAs.
The aim of the current study is to do exploratory studies to test the feasibility of developing microneedles using hot melt extrusion (HME) coupled with Fused deposition modeling (FDM) 3D printing. Two microneedles using two different polymeric carriers, AquaSolveTM Hydroxymethyl propyl cellulose acetate succinate (HPMC AS LG) (an enteric polymer) and KlucelTM Hydroxy propyl cellulose (HPC EF) (a non-enteric polymer) to form the carrier matrix with Poly ethylene Oxide (PEO N80) as a plasticizing agent and Indomethacin 20% (w/w) as a model drug was used to develop drug loaded microneedles. The resulting physical mixtures was extruded using twin-screw co-rotating 11mmm extruder (Thermo Fischer Scientific, Waltham, MA, USA). The filaments obtained from HME were then printed using FDM-3D printer (Ultimaker S3 3-D desktop printer, Geldermalsen, The Netherlands). The formulation is further analyzed for its morphology, mechanical strength, insertion depths, release profile. The application of FDM-based 3D printed for developing microneedles is a novel and versatile manufacturing method for creating personalized drug delivery devices, containing accurate and reproducible doses of medications while providing patient-tailored release profiles.
Recommended Citation
Palande, Nikeeta, "Exploratory Studies on the Feasibility of Developing Microneedles Using Hot Melt Extrusion Coupled with Fused Deposition Modeling 3-D Printing" (2022). Electronic Theses and Dissertations. 2452.
https://egrove.olemiss.edu/etd/2452
Concentration/Emphasis
Pharmaceutical Science