Date of Award
1-1-2024
Document Type
Thesis
Degree Name
M.S. in Pharmaceutical Science
First Advisor
Michael A. Repka
Second Advisor
Walter G. Chambliss
Third Advisor
Mo Maniruzzaman
Relational Format
dissertation/thesis
Abstract
This study aimed to formulate and evaluate Isoniazid-Pyridoxine-loaded gummies for use in a population ranging from pediatric to geriatric and to study the applicability of BIO X 3D printer in printing gummy formulations. Semisolid extrusion (SSE) 3D printing is an emerging technology in personalized medicine. To address clinical multi-dose requirements, SSE has been explored to manufacture new preparations. In this study, Isoniazid (INH) and Pyridoxine Hydrochloride (PDX) were used to make gummy formulations for use in the treatment of Tuberculosis. A suitable semisolid mixture for SSE was prepared and incorporated into the BIO X 3D printer for extrusion-based 3D printing and chewable 3D printed gummy formulations with 3 sizes were prepared. First, the semisolid extrudability was evaluated by combining different ratios of polymers, Xylitol, and purified water. Then, rheological tests were performed to evaluate the properties of the semisolid and the effect of Gelatin, and carrageenan, and the effect of drug load in Cartridge was studied on printability. The stability study indicates the semisolid material before printing and the 3D-printed gummy formulations can be stored for 30 days. FT-IR studies demonstrated the absence of drug-drug and drug-excipient incompatibility, drug content, and drug release profiles showing that the formulations show immediate release profiles and have uniform drug content throughout 30 days. This study provides a new strategy for formulations used to treat Tuberculosis and effectively meets the need for personalized medicine.
Recommended Citation
Holkunde, Aditi Rajendra, "Formulation Development and Characterization of Isoniazid-Pyridoxine Combination Gummies Using an Extrusion-Based 3D Printer" (2024). Electronic Theses and Dissertations. 2819.
https://egrove.olemiss.edu/etd/2819