Date of Award
1-1-2024
Document Type
Dissertation
Degree Name
Ph.D. in Pharmaceutical Sciences
First Advisor
Michael A. Repka
Second Advisor
Walt Chambliss
Third Advisor
Samir A. Ross
School
University of Mississippi
Relational Format
dissertation/thesis
Abstract
Microneedles are used to deliver drugs to the skin and the mucous membrane. Soluble polymers are used to make soluble microneedles; these polymers instantly dissolve in the tissue and release their entire drug load, including the polymer construct. To reduce the severity of side effects at the site of administration and systemic unfavorable effects, it is often better for the drug to release slowly into the tissue. Furthermore, it is safe and effective to release the active pharmaceutical ingredient (API) under controlled release, excluding the excipients.
In the first chapter, Polymer-Coated Polymeric (PCP) microneedles were fabricated using PVP K 30 for the core and ethyl cellulose for the coating. When PCP microneedles are inserted into tissue, they do not break down; instead, they remain intact, allowing drugs and analytes to diffuse both inside and outside across the membrane. This study investigated the feasibility of utilizing polymer coated polymeric microneedles to extract analytes from skin tissue. The PCP microneedles were able to extract the analytes from the skin for upto 45minutes, whereas adsorbent-loaded PCP microneedles extracted the lipophilic analytes from the skin by three and six folds higher when compared to the PCP microneedles.
Recommended Citation
Jakka, Deeksha, "Polymer Coated Microneedles, A Novel Technology for Drug Delivery and Sampling" (2024). Electronic Theses and Dissertations. 2945.
https://egrove.olemiss.edu/etd/2945