Date of Award
1-1-2025
Document Type
Dissertation
Degree Name
Ph.D. in Chemistry
First Advisor
Eden E.L. Tanner
Second Advisor
Thomas Werfel
Third Advisor
James Cizdziel
School
University of Mississippi
Relational Format
dissertation/thesis
Abstract
Targeted drug delivery remains a critical challenge in cancer therapy, particularly for triple-negative breast cancer (TNBC), a highly aggressive and heterogeneous subtype of breast cancer. Due to the absence of clear molecular targets, the TNBC primarily relies on chemotherapy, which can often lead to severe side effects and drug resistance. This complexity demands an innovative drug delivery approach to enhance tumor targeting while minimizing the side effects. This research explores novel nanoparticle and nucleic acid-based drug delivery approaches utilizing ionic liquids (ILs) to enhance extra and intra-cellular targeting, cellular uptake, cellular retention, and biocompatibility, ultimately improving the delivery efficacy.
Recommended Citation
Dasanayake, Gaya Saumya, "Leveraging ionic liquids for enhancing targeted nanoparticle and nucleic acid delivery to advance breast cancer treatments." (2025). Electronic Theses and Dissertations. 3265.
https://egrove.olemiss.edu/etd/3265
NP uptake MB231 cells (4) (1)