Date of Award
2016
Document Type
Dissertation
Degree Name
Ph.D. in Pharmaceutical Sciences
Department
Pharmacy Administration
First Advisor
John P. Bentley
Second Advisor
Marie Barnard
Third Advisor
Amit S. Patel
Relational Format
dissertation/thesis
Abstract
Objectives: The objectives of this study are to: 1) examine the psychometric properties of the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2); 2) assess the measurement invariance of the SF-12v2 with respect to age, disease severity, and treatment regimen; 3) identify psychosocial predictors of health-related quality (HRQOL) among adults with hemophilia in the United States. Methods: This cross-sectional study was conducted using both a web-based and paper-based self-administered survey. Adults with hemophilia were recruited using an online panel, a Facebook community of hemophilia patients, and at the University of Mississippi Medical Center hemophilia treatment clinic. Psychometric properties of the SF-12v2 were established in terms of its construct validity and internal consistency reliability using confirmatory factor analysis (CFA). The measurement invariance of the scale was examined using a multi-group CFA based approach. Finally, structural equation modeling (SEM) was used to test a theory driven model to identify psychosocial predictors of HRQOL in the study sample. Results A total of 218 adults with hemophilia completed the survey. The SF-12v2 was found to be psychometrically valid in the study population. The CFA revealed a two-factor model for the SF-12v2 instrument similar to what has been previously established in the literature. The instrument was found to invariant with respect to age, disease severity, and treatment regimen. Results from the SEM analysis suggested that disability, social support, maladaptive coping, and self-efficacy were key predictors of HRQOL among adults with hemophilia. Conclusions The study results indicated that the SF-12v2 is a psychometrically sound instrument to assess HRQOL of adults with hemophilia. Considering that the assumption of measurement invariance was met, future studies can consider that sub-group comparisons among hemophilia patients in terms of HRQOL reflect true differences between groups and are not artifacts of measurement bias. Clinicians and caregivers of hemophilia patients should consider factors such as improving social support provided, emphasizing on the reduction of maladaptive coping strategies, and increasing patient self-efficacy while making key treatment decisions.
Recommended Citation
Shah, Ruchit Mukesh, "Measuring And Understanding Health-Related Quality Of Life Among Adult Patients With Hemophilia" (2016). Electronic Theses and Dissertations. 743.
https://egrove.olemiss.edu/etd/743
Concentration/Emphasis
Emphasis: Pharmacy Administration