Monoamine oxidases inhibitors from Colvillea racemosa: Isolation, biological evaluation, and computational study.

Authors

• Enas Mohamed, University of Mississippi, Beni-Suef University
• Mohamed A. Zaki, University of Mississippi, Beni-Suef University
• Narayan D. Chaurasiya, University of Mississippi
• Asmaa I. Owis, Beni-Suef University
• Sameh AbouZid, Beni-Suef University
• Yan-Hong Wang, University of Mississippi
• Bharathi Avula, University of Mississippi
• Ahmed A. Seida, Cairo University
• Babu L. Tekwani, University of Mississippi
• Samir A. Ross, University of Mississippi

Department

Pharmacy

Document Type

Article

DOI

10.1016/j.fitote.2017.11.009

Publication Date

1-1-2018

Abstract

Bioassay-guided fractionation and chemical investigation of Colvillea racemosa stems led to identification of two new α, β-dihydroxydihydrochalcones, colveol A (1) and colveol B (2) along with fifteen known compounds. The structures were elucidated via interpretation of spectroscopic data. The absolute configurations of the dihydrochalcones 1 and 2 were assigned by a combination of chemical modification and electronic circular dichroism data. The isolated compounds were evaluated for their inhibition activity toward recombinant human monoamine oxidases (rhMAO-A and -B). Compound 1 demonstrated preferential inhibition against hMAO-A isoenzyme (IC

Relational Format

journal article

Recommended Citation

Mohamed, E. I., Zaki, M. A., Chaurasiya, N. D., Owis, A. I., AbouZid, S., Wang, Y.-H., Avula, B., Seida, A. A., Tekwani, B. L., & Ross, S. A. (2018). Monoamine oxidases inhibitors from Colvillea racemosa : Isolation, biological evaluation, and computational study. Fitoterapia, 124, 217–223. https://doi.org/10.1016/j.fitote.2017.11.009

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