Promoting Progress in the Rigor, Reproducibility, and Translatability of Dietary Supplement Research
Document Type
Oral Presentation
Location
Oxford Conference Center
Event Website
https://oxfordicsb.org/
Start Date
23-4-2026 1:30 PM
End Date
23-4-2026 2:00 PM
Description
The National Institutes of Health (NIH) Office of Dietary Supplements’ (ODS) Analytical Methods and Reference Materials Program (AMRM) supports the development of tools that facilitate more reproducible and reliable research on the health effects of dietary supplements. AMRM collaborates with the National Institute of Standards and Technology, the US Department of Agriculture, and others to advance development and validation of quantitative and qualitative methods, produce certified reference materials (CRMs), and support dietary supplement focused laboratory quality assurance programs. AMRM play a key role in NIH ODS’s broader efforts to improve the rigor, translatability, and trustworthiness of dietary supplement and related nutrition research. Recent advances in AMRM-supported analytical resources are presented here, including newly or soon to be released reference materials for eleuthero, black cohosh, and cyanobacteria; expansion of an online platform that integrates a dietary supplement composition database with mass spectral data processing tools; application of digitization approaches combined with chemometric data processing to HPTLC-based chemical characterization; investigations of non-targeted analyses for the characterization and authentication of botanical reference materials; and further development of an online database to help researchers identify fit-for-purpose reference materials. These AMRM-supported resources benefit researchers and industry scientists by expanding the analytical toolkit to reliably investigate dietary supplement chemical composition, and contribute to NIH ODS efforts to promote progress in the rigor with which dietary supplement research studies are designed and conducted, evaluated, and reported in the literature.
This work was supported in whole or in part by the NIH Office of Dietary Supplements and was conducted in collaboration with colleagues at NIH, the National Institute of Standards and Technology, the United States Department of Agriculture, and the National Research Council Canada.
Recommended Citation
Kuszak, Adam, "Promoting Progress in the Rigor, Reproducibility, and Translatability of Dietary Supplement Research" (2026). Oxford ICSB. 30.
https://egrove.olemiss.edu/icsb/2026_ICSB/Schedule/30
Publication Date
April 2026
Promoting Progress in the Rigor, Reproducibility, and Translatability of Dietary Supplement Research
Oxford Conference Center
The National Institutes of Health (NIH) Office of Dietary Supplements’ (ODS) Analytical Methods and Reference Materials Program (AMRM) supports the development of tools that facilitate more reproducible and reliable research on the health effects of dietary supplements. AMRM collaborates with the National Institute of Standards and Technology, the US Department of Agriculture, and others to advance development and validation of quantitative and qualitative methods, produce certified reference materials (CRMs), and support dietary supplement focused laboratory quality assurance programs. AMRM play a key role in NIH ODS’s broader efforts to improve the rigor, translatability, and trustworthiness of dietary supplement and related nutrition research. Recent advances in AMRM-supported analytical resources are presented here, including newly or soon to be released reference materials for eleuthero, black cohosh, and cyanobacteria; expansion of an online platform that integrates a dietary supplement composition database with mass spectral data processing tools; application of digitization approaches combined with chemometric data processing to HPTLC-based chemical characterization; investigations of non-targeted analyses for the characterization and authentication of botanical reference materials; and further development of an online database to help researchers identify fit-for-purpose reference materials. These AMRM-supported resources benefit researchers and industry scientists by expanding the analytical toolkit to reliably investigate dietary supplement chemical composition, and contribute to NIH ODS efforts to promote progress in the rigor with which dietary supplement research studies are designed and conducted, evaluated, and reported in the literature.
This work was supported in whole or in part by the NIH Office of Dietary Supplements and was conducted in collaboration with colleagues at NIH, the National Institute of Standards and Technology, the United States Department of Agriculture, and the National Research Council Canada.
https://egrove.olemiss.edu/icsb/2026_ICSB/Schedule/30
Comments
Adam J. Kuszak, Ph.D., is a Health Scientist Administrator in the National Institutes of Health Office of Dietary Supplements (NIH ODS) and Director of the ODS Analytical Methods and Reference Materials Program. Dr. Kuszak collaborates with researchers, industry scientists, and government agency colleagues to support scientific resource development and promote biomedical research on the composition, mechanisms, and health effects of dietary supplements and natural products. In addition, he provides scientific expertise and analyses to facilitate ODS initiative development, program management, and strategic planning. Dr. Kuszak’s primary research interests are in elucidating the mechanisms of action and effects on cellular signaling networks of natural products and therapeutics and their chemical and biological characterization. Dr. Kuszak earned his B.S. in pharmacology and toxicology from the University of Wisconsin-Madison and his Ph.D. in pharmacology from the University of Michigan. Dr. Kuszak joined ODS as an American Association for the Advancement of Science (AAAS) Science & Technology Policy Fellow in 2014, after first completing a Postdoctoral Scholar position at the National Institute of Diabetes and Digestive and Kidney Diseases and serving as a Washington Fellow at the American Society for Pharmacology and Experimental Therapeutics (ASPET). In addition to his work at NIH, Dr. Kuszak previously served as a member of the Journal of AOAC International Editorial Board and as a government liaison to the USP Dietary Supplements Admission Evaluation & Labeling Expert Committee.