The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells

Authors

Lorenzo Allegri, Università degli Studi di Udine
Federica Baldan, Università degli Studi di Roma La Sapienza
Sudeshna Roy, University of Mississippi
Jeffrey Aubé, University of North Carolina at Chapel Hill
Diego Russo, Università degli studi Magna Graecia di Catanzaro
Sebastiano Filetti, Università degli Studi di Roma La Sapienza
Giuseppe Damante, Università degli Studi di Udine

Document Type

Article

Publication Date

12-1-2019

Abstract

Copyright © 2019 Amini et al. Ferula assafoetida is a medicinal plant of the Apiaceae family that has traditionally been used for its therapeutic value. Particularly, terpenoid and phenylpropanoid metabolites, major components of the root-derived oleo-gum-resin, exhibit anti-inflammatory and cytotoxic activities, thus offering a resource for potential therapeutic lead compounds. However, genes and enzymes for terpenoid and coumarin-type phenylpropanoid metabolism have thus far remained uncharacterized in F. assafoetida. Comparative de novo transcriptome analysis of roots, leaves, stems, and flowers was combined with computational annotation to identify candidate genes with probable roles in terpenoid and coumarin biosynthesis. Gene network analysis showed a high abundance of predicted terpenoid- and phenylpropanoid-metabolic pathway genes in flowers. These findings offer a deeper insight into natural product biosynthesis in F. assafoetida and provide genomic resources for exploiting the medicinal potential of this rare plant.

Relational Format

journal article

Recommended Citation

Allegri, L., Baldan, F., Roy, S., Aubé, J., Russo, D., Filetti, S., & Damante, G. (2019). The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells. Scientific Reports, 9(1), 7374. https://doi.org/10.1038/s41598-019-43894-0

DOI

10.1038/s41598-019-43894-0