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Faculty and Student Publications
Document Type
Article
Publication Date
12-1-2019
Abstract
Copyright © 2019 Amini et al. Ferula assafoetida is a medicinal plant of the Apiaceae family that has traditionally been used for its therapeutic value. Particularly, terpenoid and phenylpropanoid metabolites, major components of the root-derived oleo-gum-resin, exhibit anti-inflammatory and cytotoxic activities, thus offering a resource for potential therapeutic lead compounds. However, genes and enzymes for terpenoid and coumarin-type phenylpropanoid metabolism have thus far remained uncharacterized in F. assafoetida. Comparative de novo transcriptome analysis of roots, leaves, stems, and flowers was combined with computational annotation to identify candidate genes with probable roles in terpenoid and coumarin biosynthesis. Gene network analysis showed a high abundance of predicted terpenoid- and phenylpropanoid-metabolic pathway genes in flowers. These findings offer a deeper insight into natural product biosynthesis in F. assafoetida and provide genomic resources for exploiting the medicinal potential of this rare plant.
Relational Format
journal article
Recommended Citation
Allegri, L., Baldan, F., Roy, S., Aubé, J., Russo, D., Filetti, S., & Damante, G. (2019). The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells. Scientific Reports, 9(1), 7374. https://doi.org/10.1038/s41598-019-43894-0
DOI
10.1038/s41598-019-43894-0