Assessment of selected Saudi and Yemeni plants for mosquitocidal activities against the yellow fever mosquito Aedes aegypti

Authors

Shaza Al-Massarani, King Saud University
Amina El-Shaibany, Sana'a University
Nurhayat Tabanca, USDA Agricultural Research Service, Washington DC
Abbas Ali, University of Mississippi School of Pharmacy
Alden S. Estep, Research Department
James J. Becnel, USDA Agricultural Research Service, Gainesville
Fatih Goger, Anadolu Üniversitesi
Betul Demirci, Anadolu Üniversitesi
Ali El-Gamal, King Saud University
K. Husnu Can Baser, Yakin Doğu Üniversitesi

Document Type

Article

Publication Date

11-1-2019

Abstract

© 2019 by the authors. Marine organisms are recognized as a source of compounds with interesting biological activities. Vibrio neocaledonicus has been reported on for its high effectiveness against corrosion in metals but it has been little studied for its chemical and biological activities. In this study, four compounds were isolated from V. neocaledonicus: indole (1); 1H-indole-3-carboxaldehyde (2); 4-hydroxybenzaldehyde (3) and Cyclo (-Pro-Tyr) (4); using a bioassay-guided method, since in a previous study it was found that the ethyl acetate extract was active on the enzymes acetylcholinesterase (AChE), alpha-glucosidase (AG) and xanthine oxidase (XO). The inhibitory activities of the three compounds against AChE, AG and XO was also evaluated. In addition, the enzymatic inhibitory activity of indole to the toxins from the venom of Bothrops asper was tested. Results showed that indole exhibited strong inhibitory activity to AG (IC50 = 18.65 ± 1.1 µM), to AChE, and XO (51.3% and 44.3% at 50 µg/mL, respectively). 1H-indole-3-carboxaldehyde displayed strong activity to XO (IC50 = 13.36 ± 0.39 µM). 4-hydroxybenzaldehyde showed moderate activity to XO (50.75% at 50 µg/mL) and weak activity to AChE (25.7% at 50 µg/mL). Furthermore, indole showed a significant in vitro inhibition to the coagulant effect induced by 1.0 µg of venom. The findings were supported by molecular docking. This is the first comprehensive report on the chemistry of V. neocaledonicus and the bioactivity of its metabolites.

Relational Format

journal article

Recommended Citation

Al-Massarani, S., El-Shaibany, A., Tabanca, N., Ali, A., Estep, A. S., Becnel, J. J., Goger, F., Demirci, B., El-Gamal, A., & Baser, K. H. C. (2019). Assessment of selected Saudi and Yemeni plants for mosquitocidal activities against the yellow fever mosquito Aedes aegypti. Saudi Pharmaceutical Journal, 27(7), 930–938. https://doi.org/10.1016/j.jsps.2019.07.001

DOI

10.1016/j.jsps.2019.07.001