Date of Award
1-1-2024
Document Type
Dissertation
Degree Name
Ph.D. in Pharmaceutical Sciences
First Advisor
Soumyajit Majumdar
Second Advisor
Walter G. Chambliss
Third Advisor
Michael A. Repka
Relational Format
dissertation/thesis
Abstract
Due to the complexity of the anatomical and physiological barriers in the eye, ocular drug delivery presents significant challenges. The poor solubility of many drugs and short retention times on the ocular surface results in low bioavailability from traditional topical dosage forms. Various types of eye infections, such as bacterial keratitis (BK) and fungal keratitis (FK), can become critical and lead to serious visual disabilities. Therefore, this research study aims to enhance the solubility and corneal permeation of two drugs, Ciprofloxacin (CIP) for BK and the antifungal agent Natamycin (NT) for FK, using nanoemulsion (NE) and cyclodextrin (CD) based technologies.
Recommended Citation
Cai, Chuntian, "Design of topical ocular drug delivery systems for management of eye keratitis" (2024). Electronic Theses and Dissertations. 2797.
https://egrove.olemiss.edu/etd/2797