Date of Award
1-1-2024
Document Type
Thesis
Degree Name
M.S. in Pharmaceutical Science
First Advisor
Eman A. Ashour
Second Advisor
Mo Maniruzzman
Third Advisor
Micheal Repka
Relational Format
dissertation/thesis
Abstract
The aim of this study was to develop an amorphous solid dispersion (ASD) of fenofibrate using Hot Melt Extrusion (HME) and 3D printing. By using HME, 3D printable filaments were prepared. Fenofibrate (10% w/w), Soluplus®, and Polyethylene oxide-N80 were used to prepare the HME filaments. The filaments were divided into two parts, the first part was used as a feedstock for the Fused disposition modeling 3D printing (FDM 3D printing) to print fenofibrate tablets with different percent infill densities, 90%, 70% and 50%. The second part was milled and filled into gelatin capsules to compare the dissolution release profile of the three different infill densities 3D printed tablets and the conventional capsules. The elasticity, strength, and stiffness of the HME filaments were assessed using a three-point bend test to evaluate their printability. The formulations were evaluated for drug content, physical state and release profile. To determine the physical state of the fenofibrate in the physical mixtures, HME filaments and 3D printed tablets, Differential Scanning Calorimetry (DSC) was performed. Fourier transform infrared spectroscopy (FTIR) was used to assess the compatibility between the drug and the polymeric carriers. Scanning Electron Microscopy (SEM) was used to evaluate the morphology of the pure fenofibrate and 3D-printed tablets. The SEM images of pure fenofibrate showed large cylindrical crystals while the 3D-printed tablets showed a smooth surface with no record of any crystals. This observation is in line with the DSC results and confirms the conversion of fenofibrate from crystalline to an amorphous state. The in- vitro drug release for the 3D printed tablets and capsules was increased 2-fold as compared to pure fenofibrate.
Recommended Citation
Deshmukh, Janhavi Santosh, "Development of Fenofibrate Solid Dispersion Via Hot Melt Extrusion and 3D Printing Technologies" (2024). Electronic Theses and Dissertations. 2803.
https://egrove.olemiss.edu/etd/2803