Date of Award
1-1-2024
Document Type
Dissertation
Degree Name
Ph.D. in Pharmaceutical Sciences
First Advisor
Michael A. Repka
Second Advisor
Eman Ashour
Third Advisor
Walt Chambliss
Relational Format
dissertation/thesis
Abstract
The drug delivery system enables the release of the active pharmaceutical ingredient to achieve a desired therapeutic response. Conventional, non-controlled drug delivery systems are unable to deliver the drug at a sustained rate which leads to poor bioavailability, fluctuations in plasma drug concentration, and potential side effects. The extended drug delivery system enables drug delivery at a sustained or predetermined rate to achieve maximum efficacy and safety. Different routes of drug administration, along with various extended-release dosage forms have been extensively developed such as oral delivery, parenteral delivery, transdermal delivery, ocular delivery, and tumor delivery among others. This dissertation developed and evaluated multiple extended drug delivery systems in three chapters.
In the first chapter, poloxamer 407-based thermosensitive hydrogel formulations are investigated as an in situ depot system for subcutaneous delivery of praziquantel. In vitro and in vivo characterizations of the formulations are discussed. In the second chapter, poly(2-ethyl-2-oxazoline) (PEtOx)-based solid oral tablets produced via hot-melt extrusion (HME) paired with fused deposition modeling (FDM) three-dimensional (3D) printing are developed and evaluated, this study is among the first to suggest PEtOx as a novel extended release excipient on HME coupled FDM 3D printing. The third chapter discusses the formulation development and scale-up of soluplus®-based polymeric micelles for improved solubility and extended drug delivery. In conclusion, this dissertation describes and discusses formulation development strategies and considerations in extended drug delivery by developing and characterizing different extended-release dosage forms.
Recommended Citation
Feng, Sheng, "Formulation Design and Development for Extended-Release Drug Delivery System" (2024). Electronic Theses and Dissertations. 2806.
https://egrove.olemiss.edu/etd/2806