Document Type
Oral Presentation
Location
Oxford Conference Center
Event Website
https://oxfordicsb.org/
Start Date
21-4-2026 1:00 PM
End Date
21-4-2026 2:30 PM
Description
Background: This study was conducted to evaluate the efficacy and safety of Red Ginseng Extract Powder (RGEP) in achieving glycemic control in prediabetic Korean subjects. Methods: The study consisted of 49 subjects in the RGEP group and 49 in the placebo group. The participants were orally given 2 tablets of RGEP and placebo (500 mg/day twice daily in the morning and the evening within 30 min after meal), respectively. The subjects were followed duration of 12-week. The participants glycemic control parameters, such as fasting blood glucose levels, 30-, 60-, 90-, and 120-min blood glucose levels at 75gm oral glucose tolerance test, Hb1Ac levels, glucose area under the curve, homeostasis model of insulin resistance, insulinogenic index, and c-peptide levels were evaluated. Moreover, hormone parameters, such as glucagon, adiponectin and glucagon-like peptide-1, and dipeptidyl peptidase-4 levels was also evaluated. Finally, the conversion rate of diabetes and Impaired glucose tolerance events were also evaluated between the case and control subjects. Results: There were significant differences in changes in fasting blood glucose and 30-, 60-, 90-, and 120-min blood glucose levels on an oral glucose tolerance test, Hb1Ac levels, glucose area under the curve, homeostasis model assessment of insulin resistance, c-peptide levels and insulinogenic index, glucagon, adiponectin, and glucagon-like peptide-1 levels at 12 weeks from baseline between the 2 groups (P < .05). There was a significant time-dependent decrease in dipeptidyl peptidase-4 levels in the RGEP group (P = .001). Finally, when we compared diabetes end-point status between the two groups, more subjects were reverted to normal glycemia in RGEP group with 22.4% vs 8.2% in control group. No subjects from RGEP group converted to diabetes but 3(6.1%) subjects from the placebo group converted to diabetes during the 12 weeks of follow-up period. In conclusion, this study revealed that Red Ginseng Extract Powder was safe and has significant benefits for improving glycemic level in high-risk for diabetes subjects.
Recommended Citation
Cho, Namhan, "Efficacy and safety of red ginseng extract powder (KGC05pg) in achieving glycemic control in prediabetes Korean subjects: A 12-week, single-center, randomized, double-blind, parallel-group, placebo-controlled study" (2026). Oxford ICSB. 10.
https://egrove.olemiss.edu/icsb/2026_ICSB/Schedule/10
Publication Date
April 2026
Accessibility Status
Screen reader accessible, Searchable text
Included in
Efficacy and safety of red ginseng extract powder (KGC05pg) in achieving glycemic control in prediabetes Korean subjects: A 12-week, single-center, randomized, double-blind, parallel-group, placebo-controlled study
Oxford Conference Center
Background: This study was conducted to evaluate the efficacy and safety of Red Ginseng Extract Powder (RGEP) in achieving glycemic control in prediabetic Korean subjects. Methods: The study consisted of 49 subjects in the RGEP group and 49 in the placebo group. The participants were orally given 2 tablets of RGEP and placebo (500 mg/day twice daily in the morning and the evening within 30 min after meal), respectively. The subjects were followed duration of 12-week. The participants glycemic control parameters, such as fasting blood glucose levels, 30-, 60-, 90-, and 120-min blood glucose levels at 75gm oral glucose tolerance test, Hb1Ac levels, glucose area under the curve, homeostasis model of insulin resistance, insulinogenic index, and c-peptide levels were evaluated. Moreover, hormone parameters, such as glucagon, adiponectin and glucagon-like peptide-1, and dipeptidyl peptidase-4 levels was also evaluated. Finally, the conversion rate of diabetes and Impaired glucose tolerance events were also evaluated between the case and control subjects. Results: There were significant differences in changes in fasting blood glucose and 30-, 60-, 90-, and 120-min blood glucose levels on an oral glucose tolerance test, Hb1Ac levels, glucose area under the curve, homeostasis model assessment of insulin resistance, c-peptide levels and insulinogenic index, glucagon, adiponectin, and glucagon-like peptide-1 levels at 12 weeks from baseline between the 2 groups (P < .05). There was a significant time-dependent decrease in dipeptidyl peptidase-4 levels in the RGEP group (P = .001). Finally, when we compared diabetes end-point status between the two groups, more subjects were reverted to normal glycemia in RGEP group with 22.4% vs 8.2% in control group. No subjects from RGEP group converted to diabetes but 3(6.1%) subjects from the placebo group converted to diabetes during the 12 weeks of follow-up period. In conclusion, this study revealed that Red Ginseng Extract Powder was safe and has significant benefits for improving glycemic level in high-risk for diabetes subjects.
https://egrove.olemiss.edu/icsb/2026_ICSB/Schedule/10
Comments
March 2024 – Present Emeritus Professor of Preventive Medicine, Ajou University School of Medicine Oct 2000 – Feb 2024 Professor of Preventive Medicine, Ajou University School of Medicine June 1997- Present Director of Clinical Epidemiology, Ajou University Hospital March 2002 – Feb 2006 Chairman of Department of Preventive Medicine. Dec. 1989 - Aug. 1994 Research Assistant Professor / Director of Biometry, Center for Endocrinology, Metabolism, and Molecular Medicine at Northwestern University Medical School, Chicago USA PROFESSIONAL POSITIONS AND APPOINTMENTS 2018-2019 President of the International Diabetes Federation 2016-2017 President Elect of the International Diabetes Federation 2017 Program chairman of Abu Dhabi World Diabetes Congress 2013-2017 Chairman of the IDF diabetes Atlas committee SCIENTIFIC PUBLICATIONS AND AWARDS Written More than 10 textbook chapters in Gestational Diabetes Mellitus, Osteoporosis, and Metabolic Syndrome, as well as co-author of Clinical Guidelines Task Force, Global Guideline for Type 2 Diabetes and Global Guideline for Gestational Diabetes Mellitus. Over 300 SCI peer reviewed publications and 100 non-SCI publications. Founder and President of Jeremiahs Hope Korea-humanitarian Medical service to Cambodia and Founder of Cambodia-Korea National Diabetes Ceneter in Kossamak Hospital, Phnom Penh Cambodia. Received the Chivalic Royal order with Mahasena Grade (Grand Officer) Insignia from the King of Kingdom of Cambodia in July 2015 for 15 years of humanitarian medical services. Received Korea ministry of health outstanding scientific award in April 2017. Received Korea ministry of Education outstanding education award in November 2022 Received Excellent educator Awards from the President of Korea in Feburary 2024 Recipient of the Asian Association for the Study of Diabetes Outstanding Epidemiologist Awards in November 2018. Appointed as Korea honorary ambassdor in September 2017.