Document Type
Oral Presentation
Location
Oxford Conference Center
Event Website
https://oxfordicsb.org/
Start Date
21-4-2026 11:30 AM
End Date
21-4-2026 11:50 AM
Description
Throughout history, medicinal plants have been used as herbal treatments in women’s health. However, they remain poorly characterized at the chemical level, limiting standardization and safety assessment. Chamaelirium luteum (false unicorn), traditionally used for reproductive health in the Eastern United States, has previously been shown to possess both conventional steroidal saponins as well as more rare open-chain saponins whose bioactivities are largely unexplored. Incorporation of C. luteum into commercial products, and subsequent overharvesting of wild populations has increased the urgency for robust methods to verify authenticity and detect adulteration. In this study, we coupled HPTLC-based profiling with detailed LC-MSMS analyses to compare metabolite distributions and bioactivities across root samples and commercial products. Resulting profiles will enable product testing and metabolite validation for this important botanical.
Recommended Citation
Strangman, Wendy; Perera, Wilmer; and Perera, Wilmer, "Metabolite profiling of Chamaelirium luteum (false unicorn) roots and related commercial products by HPTLC and LC-MSMS" (2026). Oxford ICSB. 9.
https://egrove.olemiss.edu/icsb/2026_ICSB/Schedule/9
Publication Date
April 2026
Accessibility Status
Screen reader accessible, Searchable text
Included in
Metabolite profiling of Chamaelirium luteum (false unicorn) roots and related commercial products by HPTLC and LC-MSMS
Oxford Conference Center
Throughout history, medicinal plants have been used as herbal treatments in women’s health. However, they remain poorly characterized at the chemical level, limiting standardization and safety assessment. Chamaelirium luteum (false unicorn), traditionally used for reproductive health in the Eastern United States, has previously been shown to possess both conventional steroidal saponins as well as more rare open-chain saponins whose bioactivities are largely unexplored. Incorporation of C. luteum into commercial products, and subsequent overharvesting of wild populations has increased the urgency for robust methods to verify authenticity and detect adulteration. In this study, we coupled HPTLC-based profiling with detailed LC-MSMS analyses to compare metabolite distributions and bioactivities across root samples and commercial products. Resulting profiles will enable product testing and metabolite validation for this important botanical.
https://egrove.olemiss.edu/icsb/2026_ICSB/Schedule/9
Comments
Dr. Wendy Strangman is an associate professor at UNC Wilmington in the department of chemistry and biochemistry. She earned her Ph.D. in Oceanography from the University of California, San Diego, and completed postdoctoral research at the University of British Columbia. Current research focuses on developing HPTLC-LC-MSMS coupled bioassays for rapid natural product discovery and evaluation. Additional research projects include metabolomics-based evaluation of digestive transformations for botanical extracts after oral consumption, organic carbon cycling on coral reefs, and bioactive natural product discovery from marine bacteria and harmful algal blooms. Beyond her academic pursuits, she enjoys beach volleyball, skiing, and family adventures.